pentobarbital will reduce the level or outcome of conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital will reduce the level or result of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is really a sensitive CYP3A4 substrate. Coadministration